FIGURE
Fig. 3
- ID
- ZDB-FIG-230829-21
- Publication
- George et al., 2022 - Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling
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Fig. 3
Zebrafish rerea homozygous mutants exhibit coloboma. Three-day post fertilization WT zebrafish embryos (A, B) exhibit fused optic fissure margins (54 genotyped embryos), whereas rerea homozygous mutants exhibit coloboma (E, F, 52/54 genotyped embryos). Sagittal histological sectioning of WT (C, D, N = 10 genotyped embryos) and rerea mutant (G, H, N = 10 genotyped embryos) zebrafish eye (3 dpf). The schematic in C gives the approximate plane of sectioning for the histologic sections. Coloboma showed variable penetrance in embryos at 5 dpf (I). Measurement of eye area (lateral view, Figure 2K) revealed significantly smaller eye at 3 dpf (P < .05) of rerea mutant larvae compared with WT. No statistical difference in eye size was observed at 5 dpf (J). Student's t test was used to determine level of significance and P value is provided (N = 30 genotyped embryos/group).
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
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| Observed In: | |
| Stage Range: | Protruding-mouth to Day 5 |
Phenotype Detail
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