FIGURE

Fig. 10

ID

ZDB-FIG-230405-17

Publication

Tan et al., 2022 - Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear

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Fig. 10

Analysis of sp5a and sp5l morphants. (A) Lateral views of live embryos at 24 hpf following injection at the one-cell stage with sp5a-MO and/or sp5l-MO, as indicated at the top. (B) Dorsal lateral views showing expression of genes indicated at the left under conditions indicated at the top.

Expression Data

Genes:	neurog1 pax5 sp5l
Fish:	AB AB + MO1-sp5a AB + MO2-sp5l sp5a^x69/x69 + MO2-sp5l sp5a^x69/x69; sp5l^x70/x70 + MO1-sp5a + MO2-sp5l
Condition:	chemical treatment by environment: 6-bromoindirubin-3'-oxime
Knockdown Reagents:	MO1-sp5a MO2-sp5l
Anatomical Term:	otic vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB AB + MO1-sp5a AB + MO2-sp5l sp5a^x69/x69 + MO2-sp5l sp5a^x69/x69; sp5l^x70/x70 + MO1-sp5a + MO2-sp5l
Condition:	chemical treatment by environment: 6-bromoindirubin-3'-oxime
Knockdown Reagents:	MO1-sp5a MO2-sp5l
Observed In:	otic vesicle
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 492, Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B., Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear, 139-153, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.