Gene

pax5

ID

ZDB-GENE-001030-2

Name

paired box 5

Symbol

pax5 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA binding activity. Involved in vestibular receptor cell development and vestibular reflex. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; focal segmental glomerulosclerosis 7; and renal coloboma syndrome. Is expressed in several structures, including B cell; chordo neural hinge; hindbrain neural keel; midbrain hindbrain boundary neural keel; and nervous system. Orthologous to several human genes including PAX5 (paired box 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

52 figures from 33 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu596 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Kwak et al., 2006
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pax5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Leukemia, acute lymphoblastic, susceptibility to, 3}	615545

Associated With pax5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001523	Paired domain
Domain	IPR022130	Paired-box protein 2 C-terminal
Domain	IPR043182	Paired DNA-binding domain
Family	IPR043565	PAX family
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily