FIGURE

FIGURE 9

ID

ZDB-FIG-230321-26

Publication

Brown-Panton et al., 2023 - Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 9

Gjd2b ^−/−/Cx35.1^−/− Light-ON VMR Hyperactivity is Reversed with Rod Photoreceptor Recruitment via Mesopic Light Exposure. (A) General overview of the mesopic VMR Assay. Zebrafish larvae were exposed to 5% light intensity to determine their sensitivity to mesopic vision. (B–C) Light-ON responses revealed that the recruitment of rod-PRC activity reversed the burst hyperactivity previously seen in gjd2b ^−/−/Cx35.1^−/− Light-ON VMR responses. (D–E) Light-OFF responses were reduced in gjd2b ^−/−/Cx35.1^−/− larvae. The statistical significance was determined by the Mann-Whitney test, p ≤ 0.05. The sample size (N) was 48 for WT and gjd2b ^−/−/Cx35.1^−/− larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol