FIGURE

FIGURE 6

ID

ZDB-FIG-230321-23

Publication

Brown-Panton et al., 2023 - Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish

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FIGURE 6

The Spontaneous Swimming Activity of Zebrafish Larvae in Continuous Dark (Light-OFF). (A–D) Spontaneous larval swimming activity was assessed in a free-swimming assay under dark (light-OFF) conditions for 5 min (A, B) The distance larvae swam (mm) lacking the gjd2b/Cx35.1 gene was indistinguishable from the WT. (C, D) The duration (s) of larval swimming bouts was assessed by analyzing the burst and coast swimming modalities separately. Gjd2 ^−/− /Cx35.1^−/− larvae demonstrated a significant reduction in the coast duration under darkness in comparison to the WT, suggesting that dominant swimming competence was compromised in a light-dependent manner. All else was indistinguishable from the WT. The statistical significance was determined by the Two-Way ANOVA test with the light-ON dataset, p ≤ 0.05. The sample size (N) was 72 for WT-type and gjd2b ^−/− /Cx35.1^−/− larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol