FIGURE

FIGURE 7

ID

ZDB-FIG-230321-24

Publication

Brown-Panton et al., 2023 - Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish

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FIGURE 7

The Cone Photoreceptor Cell Activity is Enhanced in gjd2b ^−/−/Cx35.1^−/− Larvae. (A) Overview of the experimental procedure. Burst activity was assessed for (B, C) Light-ON responses and (D, E) Light-OFF responses. Both WT and gjd2b ^−/− /Cx35.1 ^−/− larvae readily detected light transitions indicative of visual functionality. In comparison to the WT, gjd2b ^−/− /Cx35.1^−/− larvae were hyperactive, suggesting that they were more sensitive to light stimulation. No significant difference was found for light-OFF responses. The statistical significance was determined by a Mann-Whitney test. The sample size (N) was 48 for wild-type and gjd2b ^−/− /Cx35.1^−/− larvae.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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