FIGURE

Figure 6

ID

ZDB-FIG-230211-33

Publication

Quint et al., 2023 - Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models

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Figure 6

Ocular distribution of lama, lrrc4ca/lrrc4cb and kcnq5a/kcnq5b in zebrafish. In situ hybridization showing the distribution of lama2, lrrc4ca, lrrc4cb, kcnq5a and kcnq5b throughout the 1-year-old WT zebrafish retina. NBT/BCIP, in purple, was used to visualize the probes. Lama2 expression was mainly found in the INL and also modestly in the ONL (a). Lrrc4ca and lrrc4cb expression was found in both ONL and INL (b–c) whilst lrrc4ca expression was also detected in the PL (b) and lrrc4cb expression in the GCL (c). Kcnq5a expression was found in the PL, ONL, INL and GCL (d) whilst kcnq5b expression was found in only the ONL and the INL (e). Scale bars: 10 μm. WT: Wild Type, PL: photoreceptor layer, ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer, IPL: inner plexiform layer, GCL: ganglion cell layer.

Expression Data

Genes:	kcnq5a kcnq5b lama2 lrrc4ca lrrc4cb
Fish:	WT
Anatomical Terms:	retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer retinal photoreceptor layer
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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