Gene

lama2

ID
ZDB-GENE-060119-1
Name
laminin, alpha 2
Symbol
lama2 Nomenclature History
Previous Names
  • caf (1)
  • candyfloss (1)
  • unm teg15a
  • unm tk209
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to be an extracellular matrix structural constituent. Acts upstream of or within muscle attachment and myelination in peripheral nervous system. Predicted to be located in extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including adaxial cell; central nervous system; eye; musculature system; and otic vesicle. Used to study congenital merosin-deficient muscular dystrophy 1A and muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
38 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lama2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital merosin-deficient muscular dystrophy 1A Alliance Muscular dystrophy, congenital, merosin deficient or partially deficient 607855
Muscular dystrophy, limb-girdle, autosomal recessive 23 618138
Associated With lama2 Via Experimental Models
Human Disease Fish Conditions Citations
muscular dystrophy lama2teg15a/teg15a control Li et al., 2015
congenital merosin-deficient muscular dystrophy 1A lama2cl501/cl501 (AB) standard conditions Gupta et al., 2012
congenital merosin-deficient muscular dystrophy 1A lama2teg15a/teg15a standard conditions (4)
congenital merosin-deficient muscular dystrophy 1A lama2cl501/cl501 standard conditions Smith et al., 2017
congenital merosin-deficient muscular dystrophy 1A lama2tk209/tk209 standard conditions Hall et al., 2007
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000034 Laminin IV
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR002049 Laminin-type EGF domain
Domain IPR008211 Laminin, N-terminal
Domain IPR009254 Laminin alpha, domain I
Domain IPR010307 Laminin domain II
Family IPR050440 Laminin/Netrin Extracellular Matrix
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like domain Laminin alpha, domain I Laminin domain II Laminin G domain Laminin IV Laminin/Netrin Extracellular Matrix Laminin, N-terminal Laminin-type EGF domain
UniProtKB:G8IHU0
InterPro
3078
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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