FIGURE

Figure 4

ID

ZDB-FIG-230115-42

Publication

Bearce et al., 2022 - Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology

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Figure 4

urp1^∆P;urp2^∆P mutants and cfap298^tm304 mutants are phenotypically distinct.

(A–D) Lateral views of microcomputed tomography (µCT) reconstitutions of wild-type (A), cfap298^tm304 mutants (B), urp1^∆P;urp2^∆P double mutants (C), and cfap298^tm304;urp1^∆P;urp2^∆P triple mutants (D). All fish shown are female. Scale bar: 10 mm. (E) Total Cobb angles with each circle representing an individual fish. The mean ± s.d. is shown. p-Values are given from two-tailed unpaired student’s t tests. U — urp1^∆P;urp2^∆P double mutants; C — cfap298^tm304 mutants; UC — cfap298^tm304;urp1^∆P;urp2^∆P triple mutants. (Fi) Dorsal views of µCT reconstitutions with ribs and fins removed. Scale bar: 5 mm. (Fii) Quantitation of degree of lateral curvature for wild type (n=5) and urp1^∆P;urp2^∆P (n=8), uts2r3^b1436 (n=3), cfap298^tm304 (n=3), and cfap298^tm304;urp1^∆Purp2^∆P (n=6) mutants. y-axis is the arbitrary units.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cfap298^tm304/tm304 urp2^b1421/b1421; urp1^b1420/b1420 (AB) cfap298^tm304/tm304; urp2^b1421/b1421; urp1^b1420/b1420 (AB)
Observed In:	female organism skeletal system development vertebral column vertebral column anterior region vertebral column posterior region
Stage:	Adult

Phenotype Detail

Acknowledgments

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Figure 4

Figure 4

urp1∆P;urp2∆P mutants and cfap298tm304 mutants are phenotypically distinct.

urp1^∆P;urp2^∆P mutants and cfap298^tm304 mutants are phenotypically distinct.