FIGURE

Figure 4

ID

ZDB-FIG-221214-48

Publication

Chrispell et al., 2022 - Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP

Other Figures

All Figure Page

Back to All Figure Page

Figure 4

Recovery of the cone-mass receptor potential in grk KO zebrafish larvae treated with forskolin. Treated larvae were subjected to successive stimuli using a dual flash paradigm of a 20-ms flash of saturating white light (1000 cd/m²) with an interstimulus interval (ISI) ranging from 0.75 s to 5 s. Cone-mass receptor potential recovery was plotted as the ratio of the maximum isolated cone mass receptor potential response of the second stimulus to that of the initial stimulus for (A) grk1b−/− and (B) grk7a−/− larvae. A linear mixed model analysis of covariance found a significant effect of forskolin compared to vehicle (DMSO, dimethyl sulfoxide) for grk1b−/− (F_{(1, 224)} = 17.82; p <0.0001) larvae, but not grk7a−/− larvae (F_{(1, 340)} = 2.363; p = 0.1252). Error bars represent SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.