FIGURE

Figure 6

ID

ZDB-FIG-221211-192

Publication

Gebuijs et al., 2022 - Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae

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Figure 6

Relative expression levels in 5 dpf wild type zebrafish larvae treated with 5 µM of BGJ398.

Exposure windows were 0–12 and 24–36 hpf. Exposed fish (n = 8) were compared to a DMSO control (n = 8, final concentration 0.1%). (A) Expression of fgfr s showing differential expression in fgfr1a, fgfr1b, fgfr2 and fgfr4. (B) Expression of genes involved in bone formation. (C) Genes involved in cartilage formation. From col9a1b one outlier (p < 0.01 in Grubbs’ test) was removed. (D) Neural crest cell marker genes. All data are presented as box plots, with median represented by a line within the box; interquartile ranges by the boxes, 5–95 confidence intervals by whiskers and means indicated by “+” symbol. All the data were analyzed using a Kruskal–Wallis test followed by a Dunn’s multiple comparison test. Asterisks indicate significant differences; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.

Expression Data

Genes:	col1a1a col1a2 col2a1a col9a1a col9a1b dlx2a fgf3 fgf8a fgfr1a fgfr1b fgfr2 fgfr3 fgfr4 nkx3-2 runx2a runx2b sp7
Fish:	WT
Condition:	chemical treatment by environment: BGJ-398
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: BGJ-398
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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