FIGURE

Figure 3

ID

ZDB-FIG-221211-187

Publication

Gebuijs et al., 2022 - Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae

Other Figures

All Figure Page

Back to All Figure Page

Figure 3

Relative expression levels of 17 genes at 5 dpf in wildtype (n = 14), fgfr2^+/− (n = 18) and ^−/− (n = 12) zebrafish larvae.

(A) Expression of fgfr s reveals that fgfr2 is downregulated in our mutants. (B) Expression of genes involved in bone formation. (C) Genes involved in cartilage formation were not significantly different among groups. (D) Neural crest cell marker genes. In the box plots the median is represented by the line within the box; the box shows interquartile ranges. Whiskers are drawn down to the 5th and up to the 95th percentile. Points below and above the whiskers are drawn as individual dots. The mean is indicated by a “+” symbol. All the data were analyzed using a Kruskal–Wallis test followed by a Dunn’s multiple comparison test. Asterisks indicate significant differences; ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.

Expression Data

Genes:	col1a1a col1a2 col2a1a col9a1a col9a1b dlx2a fgf3 fgf8a fgfr1a fgfr1b fgfr2 fgfr3 fgfr4 nkx3-2 runx2a runx2b sp7
Fish:	WT fgfr2^{sa10729/sa10729} fgfr2^sa10729/+
Anatomical Term:	whole organism
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgfr2^{sa10729/sa10729} fgfr2^sa10729/+
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Peer J.