FIGURE

Figure 1

ID

ZDB-FIG-221118-116

Publication

Sebo et al., 2022 - Functional identification of the zebrafish Interleukin-1 receptor in an embryonic model of Il-1β-induced systemic inflammation

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Figure 1

In silico identification of the putative zebrafish interleukin-1 receptor, type 1 (Il1r1). (A) Alignment of human, mouse, and zebrafish genomic regions showing conserved synteny. Shown here are the human and mouse IL-1 receptor clusters and the putative zebrafish IL-1 receptor cluster (not to scale). (B) Phylogenetic alignment of human IL1R protein sequences with putative zebrafish Il1r protein sequences. (C) Predicted protein structures of human IL1R1, zebrafish CABZ (CABZ01054965), and zebrafish ZMP (ZMP:0000000936) showing conserved domains: N-terminal signal peptide (SP), 3 extracellular immunoglobulin-like (Ig-l) domains (Ig-l 1, Ig-l 2, and Ig-l 3), a single transmembrane domain (TM), and an intracellular Toll/Interleukin-1 receptor (TIR).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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