FIGURE

FIGURE 5

ID

ZDB-FIG-221105-5

Publication

Chen et al., 2022 - TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration

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FIGURE 5

Locomotor capacity is reduced in tfg morphants. (A) Percentages of embryos with developmental defects in control versus tfg morphants at 3 dpf. (B) A time‐course plot of percent survival in control versus tfg morphants for 3 days. (C) Digital tracks and heatmap image in larvae from control‐MO‐ and tfg‐MO‐injected groups at 5 dpf. (D–G) Statistical analyses of the average total movement distance, mobility, velocity, and maximum acceleration in the tfg‐MO and control groups (mean ± SEM; ANOVA; ***p < 0.0001; n = 10). dpf, days postfertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ml2Tg + MO1-tfg ml2Tg + MO2-tfg
Knockdown Reagents:	MO1-tfg MO2-tfg
Observed In:	swimming behavior whole organism
Stage Range:	Shield to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ CNS Neurosci Ther