FIGURE

Fig. 5

ID

ZDB-FIG-221023-28

Publication

Marom et al., 2021 - COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay

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Fig. 5

Figure 5. Copb2 heterozygous mice exhibit low bone mass phenotype

(A) Micro-CT analysis of spine showed significant decrease in bone architectural parameters in Copb2^+/− mice (Het), including the bone volume/total volume (BV/TV, p = 0.014 for males, p = 0.0006 for females) and trabecular thickness (p = 0.007 for males, p < 0.0001 for females). Females also showed decreased trabecular number (p = 0.002).

(B) Micro-CT analysis of femurs showed mild reduction in cortical thickness in the females (p = 0.003).

Mean values ± SD are indicated for both (A) and (B) (^∗p < 0.05, ^∗∗p < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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