FIGURE

Fig. 4

ID

ZDB-FIG-221023-27

Publication

Marom et al., 2021 - COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Figure 4. Structural integrity of the ER and Golgi apparatus and protein secretion are compromised in copb2^b1327/b1327 zebrafish mutants

(A–F) Confocal sections of the notochord. Immunolabeling of KDEL in copb2 siblings (A) and copb2^b1327/b1327 mutant (B) embryos. Immunolabeling of GM130 in copb2 siblings (C) and copb2^b1327/b1327 mutant (D) embryos. Immunolabeling of type II collagen in copb2 siblings (E) and copb2^b1327/b1327 mutant (F) embryos (anterior is to the left and dorsal to the top). Images were taken at the level of the yolk extension at 30 hpf.

Expression Data

Antibodies:	Ab1-col2a Ab1-golga2 Ab3-hspa5
Fish:	AB/TU copb2^b1327/b1327 (AB/TU)
Anatomical Terms:	notochord notochord endoplasmic reticulum notochord Golgi apparatus
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	copb2^b1327/b1327 (AB/TU)
Observed In:	notochord notochord endoplasmic reticulum notochord Golgi apparatus
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Hum. Genet.