FIGURE

Fig. 4

ID

ZDB-FIG-220812-33

Publication

Verwilligen et al., 2022 - Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish

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Fig. 4

Fig. 4. Stabilins are an important player in zebrafish total-body cholesterol homeostasis after challenged with a 10 day high cholesterol diet (HCD).

(A) Relative expression of stab1 and 2 in ABTL zebrafish (15 dpf old) after 10 day normal (CTRL) or either 10 day high cholesterol diet (HCD). (B) Whole body total cholesterol levels in 15dpf ABTL and stab1^−/−stab2^−/− zebrafish fed with a HCD for 10 days. (C) The effect of stab1 and 2 deficiency after 10 days of HCD on relative expression of genes involved in cholesterol acquisition (D) scavenging and (E) cholesterol efflux. Means ± SEM (n = 7; pool of 5 fish); p < 0.01**; p < 0.001***.

Expression Data

Genes:	abca1a abcg1 cd36 hmgcra ldlra marco scarb1 srebf2 stab1 stab2
Fish:	AB/TL stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)
Condition:	high cholesterol
Anatomical Term:	whole organism
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)
Condition:	high cholesterol
Observed In:	whole organism whole organism cholesterol
Stage:	Days 14-20

Phenotype Detail

Acknowledgments

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