FIGURE

Fig. 1

ID

ZDB-FIG-220812-30

Publication

Verwilligen et al., 2022 - Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish

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Fig. 1

Fig. 1. Absence of scavenger receptors stab1 and/or stab2 reduces oxLDL uptake by endothelial cells.

(A) Schematics of experimental set-up; injection of fluorescent labeled lipoproteins in 3 dpf ABTL or stabilin knockout zebrafish larvae. (B) Photomicrographs showing an overview of 3 dpf ABTL, stab1^−/−, stab2^−/−, and stab1^−/−stab2^−/− zebrafish larvae after injection of oxLDL (0.5 mg/mL; green). (C) Uptake of oxLDL (0.5 mg/mL; green) in the caudal vein of 3dpf ABTL, stab1^−/−, stab2^−/− and stab1^−/−stab2^−/− zebrafish larvae. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stab1^ibl3/ibl3 (AB/TL) stab2^ibl2/ibl2 (AB/TL) stab1^ibl3/ibl3; stab2^ibl2/ibl2 (AB/TL)
Observed In:	blood vessel endothelial cell receptor-mediated endocytosis involved in cholesterol transport
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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