FIGURE

Fig. 3

ID

ZDB-FIG-220520-40

Publication

Whyte-Fagundes et al., 2022 - Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

a Electrophysiological recordings of PTZ treatment showed interictal-like epileptiform discharges (IED) in all genotypes. Representative IEDs show most similarities between TL and panx1b^−/− events. b Quantification of IEDs for the first hour of recording for all genotypes revealed that DKO (P = 1.3 × 10⁻³, n = 12) and panx1a^−/− (P = 0.02, n = 8) had significantly fewer IEDs. No significant difference was found in the amount of IEDs for panx1b^−/− larvae compared to TL (P = 0.34, panx1b^−/− n = 9, TL n = 7). Data presented as an average number of events per hour ± s.e.m. N = number of larvae. Scale bar: 0.2 mV by 0.5 s. *P < 0.05, **P < 0.01, Mann–Whitney U test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT panx1a^yku1/yku1 panx1b^yku2/yku2 panx1a^yku1/yku1; panx1b^yku2/yku2
Condition:	chemical treatment by environment: pentetrazol
Observed In:	optic tectum neuronal action potential
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Commun Biol