Fig. 3

a Electrophysiological recordings of PTZ treatment showed interictal-like epileptiform discharges (IED) in all genotypes. Representative IEDs show most similarities between TL and panx1b^−/− events. b Quantification of IEDs for the first hour of recording for all genotypes revealed that DKO (P = 1.3 × 10⁻³, n = 12) and panx1a^−/− (P = 0.02, n = 8) had significantly fewer IEDs. No significant difference was found in the amount of IEDs for panx1b^−/− larvae compared to TL (P = 0.34, panx1b^−/− n = 9, TL n = 7). Data presented as an average number of events per hour ± s.e.m. N = number of larvae. Scale bar: 0.2 mV by 0.5 s. *P < 0.05, **P < 0.01, Mann–Whitney U test.