FIGURE
Fig. 6
- ID
- ZDB-FIG-220202-10
- Publication
- Manchanda et al., 2021 - Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 6
Loss of the TMD reduces expression of otoferlin in cell culture. (A) Representative images of cells transfected with CFP-VAMP and either WT mouse otoferlin or ΔTMD, a mouse otoferlin with a mutation matching the otofB mutation. (B) Representative images of cells labeled with 4′,6-diamidino-2-phenylindole (blue), wheat germ agglutinin for the cell membrane (red), and otoferlin (green). (C) Quantitation of the intensity of otoferlin from transfected HEK cells (t test, p < 0.001). Scale bar for A and B = 2 µm, and 10 µm for C and D. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Mol. Biol. Cell