FIGURE

Fig. 3

ID

ZDB-FIG-220113-2

Publication

Mullapudi et al., 2019 - Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function

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Fig. 3

sFlt1 expression in ?-cells severely impairs their function. (A-C) Confocal projection images of the vasculature (white) in 120?hpf Tg(fli:GFP) larvae, in combination with the indicated transgenic line. Yellow dashed lines outline the pancreas. A?-C? show the endothelial cells. (A?-C?) Confocal planes of ?-cells (red) and the surrounding vasculature (white) in 120?hpf Tg(fli:GFP) larvae, in combination with the indicated transgenic line. (D) Percentage of ?-cells responsive to physiological (?Glucose) and exogenous (+Glucose) glucose, measured as visual fluctuations in fluorescence in 120?hpf Tg(ins:GCaMP5) larvae, n=5-17 animals. (E) Glucose levels in 120?hpf animals, n=4-6 replicates, 10 animals per replicate. Data are mean�s.e.m; individual data points are shown. P-values from t-tests are presented. A, anterior; D, dorsal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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