FIGURE

Fig. 1

ID

ZDB-FIG-220112-12

Publication

Mullapudi et al., 2019 - Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function

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Fig. 1

β-Cell-specific dnVegfaa expression disrupts pancreatic islet architecture. (A,B) Pancreatic β-cells (red) and the endothelial cells (green) in 28 hpf Tg(ins:Tomato); Tg(fli:GFP) and Tg(fli:GFP); Tg(ins:dnvegfaa) embryos, viewed ventrally. (C,D) Pancreatic endocrine cells (green) and β-cells (red) in 48 hpf Tg(NeuroD:GFP); Tg(ins:DsRed) and Tg(NeuroD:GFP); Tg(ins:dnvegfaa) embryos, viewed ventrally. (E-F) Confocal projection images of Tg(ins:Tomato); Tg(fli:GFP) and Tg(ins:dnvegfaa); Tg(fli:GFP) embryos from 34 to 48 hpf, viewed laterally. Yellow arrowheads point to dispersing β-cells. Maximum intensity projections are presented. A, anterior; D, dorsal.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bns282Tg; nl1Tg
Observed In:	endocrine pancreas blood vasculature primary islet
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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