FIGURE

Fig 5

ID

ZDB-FIG-211116-14

Publication

Bühler et al., 2021 - Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish

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Fig 5

Hdac1 mRNA injection rescues the bal phenotype.

(A-E) Lateral view of uninjected and hdac1 mRNA injected wildtyp (A, C) or bal embryos (B, D) at 72 hpf, injection of mRNA prevents the bal phenotype in mutant embryos (uninjected 0 ± 0%, hdac1 mRNA injected 47.4 ± 14.76%, n = 50 embryos). (F-I) Cardiomyocytes (red) in Tg(myl7:mCherry), bal;Tg(myl7:mCherry) and hdac1 mRNA injected bal;Tg(myl7:mCherry) hearts. Hdac1 mRNA injection prevents the loss of ventricular cardiomyocytes in bal mutant embryos. (J-N) Statistical analysis of pH3⁺ cardiomyocytes after hdac1 mRNA injection in bal;Tg(myl7:mCherry) mutant embyos (wt: 4.2 ± 1.40; bal: 0.9 ± 0.88; bal + hdac1 mRNA: 2.9 ± 1.37, n = 10) and the relative proliferation rate (wt: 2.19 ± 0.66%; bal: 0.70 ± 0.68%; bal + hdac1 mRNA: 1.48 ± 0.69%, n = 10). Error bars indicate s.d.; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns, not significant.

Expression Data

Gene:	mCherry
Fish:	ulm106Tg (AB) hdac1^{ulm107/ulm107}; ulm106Tg (AB)
Anatomical Term:	cardiac muscle cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^{ulm107/ulm107}; ulm106Tg (AB)
Observed In:	cardiac muscle cell cell population proliferation cardiac ventricle cardiac ventricle cardiac muscle cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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