FIGURE

Figure 3

ID

ZDB-FIG-211103-3

Publication

Heylen et al., 2021 - Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish

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Figure 3

Histopathological analysis reveals that kainic acid (KA) injection induces whole brain abnormalities. Representative images of hematoxylin and eosin (H&E) staining on paraffin cross-brain sections of KA-injected larvae in comparison to VHC-injected siblings. (A) Abnormal brain shape was observed at 2–3 hpi until 4 dpi, marked with red arrows. Scale bar 500 μm. Selected brain abnormalities in KA-injected larvae from different parts of the brain at 3–6 hpi (B,C), 1 dpi (D,E) and 3 dpi (F,G). Red rectangles and arrows highlight the histopathological changes and its magnification. DT, dorsal thalamus; E, epiphysis; EmT, eminentia thalami; Ha, habenula; Hr, rostral hypothalamus; lfb, lateral forebrain bundle; P, pallium; PT, posterior tuberculum; Rve, rhombencephalic ventricle; TeO, optic tectum; VT, ventral thalamus.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2
Condition:	chemical treatment by injection: kainate(1-)
Observed In:	brain brain white matter eye grey matter neuronal cell body
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.