FIGURE

Figure 7

ID

ZDB-FIG-211029-111

Publication

Crouzier et al., 2021 - Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish

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Figure 7

Effect of the Tunicamycin (Tun, 2 µg/mL, 24 h) challenge on mitochondrial respiration of the zebrafish larvae at 5 dpf analyzed using the Seahorse XF mito stress test. (A) Profiles of oxygen consumption rate (OCR) during the assay. (B) Basal respiration, (C) ATP production, (D) maximal respiration, (E) proton leak, (F) non-mitochondrial respiration. Data are shown as mean ± SEM from the number of larvae indicated in (B). Abbreviations: Oligom, oligomycin (25 μM); FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (8 μM); Rot/Anti A, rotenone + antimycin A (15 μM). ** p < 0.01, *** p < 0.001 vs. V-treated; °°° p < 0.001 vs. s1r^WT; Newman-Keuls’ test after a two-way ANOVA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT sigmar1^f19/f19
Condition:	chemical treatment by environment: tunicamycin
Observed In:	ATP biosynthetic process cellular respiration regulation of mitochondrial ATP synthesis coupled proton transport
Stage:	Day 5

Phenotype Detail

Acknowledgments

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