FIGURE

Fig. 6

ID

ZDB-FIG-210825-15

Publication

Luo et al., 2021 - Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

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Fig. 6

Blockade of Akt activation inhibits hepatocarcinogenesis in zebrafish. a Expression levels of Pten, Akt, and pAkt in liver tissues from 1-month-old fabp10^WT, pten KO and pten;tp53 cKO fish. b Representative histological images of liver tissues from pten KO and pten;tp53 cKO fish treated with or without MK-2206. Scale bar, 100 μm. c Immunoreactivity of pAkt, Pcna, pHH3, and Gs in liver tissues from pten KO and pten;tp53 cKO fish treated with or without MK-2206. Scale bars, 100 μm. d Quantification of the percentages of Pcna-positive cells in liver tissues from pten KO and pten;tp53 cKO fish treated with or without MK-2206 (n = 10 random fields of view). e The tumour incidences were significantly suppressed by MK-2206 treatment in 3-month-old pten KO and pten;tp53 cKO fish. The data are shown as the mean ± SEM values

Expression Data

Antibodies:	Ab4-pten Ab5-akt Ab5-akt1 Ab5-glul Ab18-pcna
Fish:	ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}; tp53^{zf3638/zf3638}
Condition:	chemical treatment by environment: MK-2206
Anatomical Term:	liver
Stage Range:	Days 30-44 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}; tp53^{zf3638/zf3638}
Condition:	chemical treatment by environment: MK-2206
Observed In:	liver liver hepatocellular carcinoma
Stage Range:	Days 30-44 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.