FIGURE

Fig. 2

ID

ZDB-FIG-210825-10

Publication

Luo et al., 2021 - Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

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Fig. 2

Disruption of tissue-specific Pten or Tp53 expression in larvae and mature zebrafish. a Representative images of whole-mount in situ hybridization using an anti-sense RNA probe against Cas9 mRNA in 3 dpf WT and fabp10^WT larvae (black arrows). Scale bars, 500 μm. b, c Representative images of mCherry (red) and endogenous Tp53 or Pten (green, FITC-labelled) expression in liver tissues of 1-month-old tp53 KO, pten KO, and fabp10^WT control fish. Scale bars, 50 μm

Expression Data

Gene:	Cas9
Antibodies:	Ab4-pten Ab11-tp53
Fish:	ptena^{zf3641/zf3641} ptenb^{zf3644/zf3644} tp53^{zf3638/zf3638} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}
Anatomical Term:	liver
Stage Range:	Protruding-mouth to Days 30-44

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^{zf3638/zf3638} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}
Observed In:	liver
Stage:	Days 30-44

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.