FIGURE

Fig. 5

ID

ZDB-FIG-210825-14

Publication

Luo et al., 2021 - Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish

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Fig. 5

Histological and prognostic comparison of hepatocarcinogenesis between zebrafish and humans. a Tumour incidence rates in pten KO and pten;tp53 cKO fish (n = 100 per group with triplicates). The tumour incidence rates were confirmed by histological examination of dissected pten KO and pten;tp53 cKO fish at different time points. b Quantification of the malignancy of the tumours derived from fish with various mutations at 3 or 6 months of age. c Representative histological images indicating the expression of GS, PCNA, pHH3, and pAkt in tumours derived from humans and zebrafish with different mutations (fabp10^WT, pten KO and pten;tp53 cKO fish). Scale bars, 100 μm. d, e PCNA expression was correlative with prognosis in HCC patients (n = 97, d) and pten;tp53 cKO fish (n = 100, e). f Correlation between PCNA expression and malignancy grade in HCC patients (n = 97), pten KO (n = 30), and pten;tp53 cKO fish (n = 28). The data are shown as the mean ± SEM values. *p < 0.05, **p < 0.01, ***p < 0.001

Expression Data

Antibodies:	Ab5-akt Ab5-glul Ab18-pcna
Fish:	ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}; tp53^{zf3638/zf3638}
Anatomical Term:	liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644} ptena^{zf3641/zf3641}; ptenb^{zf3644/zf3644}; tp53^{zf3638/zf3638}
Observed In:	liver liver hepatocellular carcinoma
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.