RPE motif enrichment analysis.a Representative TF binding motifs enriched in RPE DOCRs as identified by HOMER. Analysis of the binding motif similarity among TFs of the bHLH family (http://jaspar.genereg.net). b Circoplot illustrating the co-occupancy rate of TFBS in the same DOCRs for the main TFs identified in the motif enrichment analysis. c Circoplot illustrating the degree of co-regulation between TFs regulating the same gene through different DOCRs. d Average percentage of co-occupancy in the same DOCR for two different TF in the RPE and NR. e Average percentage of two different TF regulating the same gene through different DOCRs in the RPE and NR.
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