ZFIN Image: Zhao et al., 2021, Fig. 1

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Figure Caption

Fig. 1 Loss of miR-1 in zebrafish results in craniofacial, pigment cell and cardiac defects. In situ hybridization of miR-1 in (A) wild-type and (B) mutant zebrafish at 24 hpf. (C) Zebrafish larvae at 72 hpf with mutants exhibiting mandibular retrognathia (left arrow) and edema around the heart (right arrow). (D) Alcian blue staining at 96 hpf. (E) Quantitative analysis of b/a. (F) Quantitative analysis of c/a. a, width between ch; b, distance between mc and ch; and c, the distance between pq and ch. (G) Quantitative analysis of head size. (H) Distribution and number of iridophores at 72 hpf. Data are presented as the mean ± standard deviation (n=5). *P<0.05 and **P<0.01 vs. WT. WT, wild-type; hpf, hours post-fertilization; miR-1, microRNA-1; mc, Meckel's cartilage; pq, palatoquadrate; ch, ceratohyal cartilage.

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Acknowledgments

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