FIGURE

Fig. 4

ID

ZDB-FIG-210218-103

Publication

Cao et al., 2021 - Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration

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Fig. 4

FK506-induced blastemas are essential to the continuous regeneration of the PCE. (A) Experimental scheme illustrating the FK506 treatment from 0 to 1 dpa and analysis at 5 dpa. (B and C) The FK506 treatment illustrated in A did not induce blastema formation and regeneration of the PCE (n = 6/7). (D) Experimental scheme illustrating the FK506 treatment from 0 to 2 dpa and analysis at 5 dpa. (E and F) The FK506 treatment was continuous up to 2 dpa when PCE blastemas formed (indicated by arrows), which led to the continuous regeneration of the PCE at 5 dpa (n = 5/9). P, proximal; D, distal. (Scale bars: 500 µM.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	amputation: caudal fin, chemical treatment by environment: tacrolimus (anhydrous)
Observed In:	regenerating fin polarity specification of proximal/distal axis
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA