FIGURE

Fig. 7

ID

ZDB-FIG-210217-62

Publication

Turan et al., 2020 - The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

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Fig. 7

Figure 7. Computer simulations of rabbit ventricular myocytes. Cardiomyocytes were paced at 2.5 Hz under three different conditions: transduced with adenovirus encoding GFP with intracellular sodium concentration [Na⁺]i unclamped (red traces); adenovirally transduced causing LITAF overexpression with [Na⁺]i unclamped (blue traces); and adenoviral overexpression of LITAF with [Na⁺]i clamped to the same average steady-state 11 mm value reached under GFP (green traces). Transmembrane voltage V (A), cytosolic calcium concentration [Ca2⁺]iB), [Na⁺]i C), L-type calcium current ICa,L (D), Na⁺/Ca²⁺ exchanger current INCX (E), Na⁺/K⁺-pump current INaK (F), slowly activating delayed rectifier K⁺ current IKs (G), rapidly activating delayed rectifier K⁺ current IKr (H), fast sodium current INa (I), and late sodium current INaL (J).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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