FIGURE

Fig. 3

ID

ZDB-FIG-210131-3

Publication

Facchinello et al., 2021 - Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

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Fig. 3

Effects of Polg mutation on heart and gonads of adult zebrafish.

A Cardiac EE histology shows a clear reduction of the thickness of the trabecular network in mutant hearts; a atrium, cm compact myocardium, t trabeculae, v ventricle. B Ovarian EE histology detects oocyte maturation defects in mutant females; black arrowheads indicate debris of atretic follicles. po primary oocyte, cao cortical-alveolar oocyte, vo vitellogenic oocyte. C Testicular EE histology detects a reduced amount of spermatozoa (sp) in mutant males. Concentration (D), velocity (E) and viability (F) of ejaculated sperm. Depicted is mean ± SEM. ***p < 0.001; N = 10, in triplicate. G Illustrative image of fluorescence staining evidencing a higher amount of dead (red) over alive (green) sperm in polg^{sa9574/sa9574} males.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	polg^{sa9574/sa9574}
Observed In:	oocyte maturation sperm testis trabecular layer zona radiata
Stage:	Adult

Phenotype Detail

Acknowledgments

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