FIGURE

Figure 2—figure supplement 1.

ID

ZDB-FIG-201229-63

Publication

Keefe et al., 2020 - Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

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Figure 2—figure supplement 1.

Zebrafish <italic>eif2b4<sup>sa17367/sa17367</sup></italic> allele characterization.

(A) BF image of 6 dpf eif2b4^{sa17367/sa17367} shows a lack of swim bladder (arrowhead) and a small head. (B) Motor swimming analysis shows impaired swimming behavior in homozygous mutants. Distance moved, time spent moving, and velocity, for wild-type controls, and eif2b5^zc103 heterozygous and homozygous mutants, at 5 dpf. Mean shown with 95% confidence intervals. (C) eif2b4^{sa17367/sa17367} mutants have impaired survival, with <5% surviving past 10 dpf (total n = 100). (D) eif2b4^{sa17367/sa17367} mutants have activation of ISR transcripts (qRT-PCR).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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