FIGURE

Fig 1

ID

ZDB-FIG-201121-48

Publication

Schindler et al., 2020 - Adriamycin does not damage podocytes of zebrafish larvae

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Fig 1

Evaluation of phenotype, autofluorescence, vascular eGFP fluorescence, survival and edema rate of larvae after treatment.

Treated larvae did not develop periocular or pericardial edemas at a significant rate (A, D, G). However, high concentrations of ADR caused an increase in mortality of the larvae (H). All doses of ADR led to a strong accumulation of ADR in the intestinal tract which caused a remarkable autofluorescence over a wide spectrum (B, E). Quantification of the vascular eGFP fluorescence of DBP larvae (Tg(-3.5fabp10a:gc-eGFP) after ADR treatment did not reveal a significant vascular reduction of the eGFP-DBP fusion protein (~68 kDa) (C, F, I). Scale bar in D represents to 200 μm, in F* to 50 μm. *P = 0,03.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; mpv17^a9/a9; lri500Tg
Condition:	chemical treatment by environment: doxorubicin
Observed In:	glomerular filtration
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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