FIGURE

Fig 4

ID

ZDB-FIG-201121-27

Publication

Schindler et al., 2020 - Adriamycin does not damage podocytes of zebrafish larvae

Other Figures

All Figure Page

Back to All Figure Page

Fig 4

Morphology and ultrastructure of larval glomeruli.

Morphological investigations by Richardson‘s staining of semithin sections (500 nm) did not show abnormalities of the glomerular morphology due to ADR treatment (A, B). Ultrastructural analysis of the pronephric filtration barrier confirmed the abscence of a glomerular phenotype (C-F). The interdigitating pattern of podocyte foot processes (asterisk in E and F) is present in both control was well as 60 μM ADR-treated larvae. The slit membrane as a highly organized structure connecting foot processes was not affected by ADR (arrows in E and F). Scale bars in A and B represent 10 μm, in C and D 1 μm, in E and F 200 nm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: doxorubicin
Observed In:	glomerular basement membrane
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One