FIGURE

FIGURE 8

ID

ZDB-FIG-201003-27

Publication

Sundaramurthi et al., 2020 - Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

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FIGURE 8

TubA plays a multifaceted role to improve visual function and preserve photoreceptors. (A,B) A total of 347 proteins were identified to be differentially expressed between 3–6 dpf vehicle-control and TubA-treated atp6v0e1^–/–. 23 proteins were upregulated (red) and 50 proteins downregulated (blue), with a cut-off of fold change ± 1.2 and –log p-value ≥ 1.3, as shown by the volcano plot and heatmap. Student’s T-Test was used for statistical analysis. (C) Table listing the most significantly down- and upregulated proteins. (D) Graphical representation of significantly downregulated and upregulated pathways in TubA-treated atp6v0e1^–/– as identified by KEGG pathway analysis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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