FIGURE

FIGURE 5

ID

ZDB-FIG-201003-24

Publication

Sundaramurthi et al., 2020 - Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness

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FIGURE 5

Iron supplementation did not restore vision in atp6v0e1 mutants. (A) Schematic diagram depicting the 4,098 bp deletion in the atp6v0e1 subunit identified through whole genome sequencing. (B) Treatment of atp6v0e1^–/– with 100 μM Fe (III) citrate, co-supplemented with 100 μM ascorbic acid and 1 mg/ml of lactoferrin daily for 3 days, did not restore visual function as measured by OKR. Experiments were performed in duplicate and Student’s T-Test was used for statistical analysis.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT atp6v0e1^ucd6/ucd6
Condition:	chemical treatment by environment: ascorbic acid
Observed In:	optokinetic behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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