FIGURE

Fig 6

ID

ZDB-FIG-200620-14

Publication

Ang et al., 2020 - Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish

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Fig 6

Absence of retinal regeneration in <italic>mdka</italic><sup><italic>mi5001</italic></sup> at 28 dpl following the death of inner retinal neurons.

(A, B) BrdU-labeled regenerated retinal neurons in wildtype (A) and mdka^mi5001 (B) retinas at 28 dpi. Arrows indicated BrdU-labeled rod photoreceptors. (C) The number of BrdU-positive cells wildtype (125.2 ± 37.1 cells) and mdka^mi5001 (33.2 ± 14.4 cells, p = 0.000341) retinas at 28 dpi. (D,E) Regenerated inner neurons labeled with HuC/D in wildtype (D) and mdka^mi5001 (E) at 28 dpi. Arrowheads indicate regenerated inner neurons are displaced in the inner plexiform layer. (F) The number of HuC/D cells in wildtype (224.8 ± 74.6 cells) and mdka^mi5001 (76.8 ± 61.4 cells, p = 0.00021) at 28 dpi. Student’s t-test, p*<0.05, n = 9 wildtype and 9 mutants. ONL: outer nuclear layer; INL: inner nuclear layer.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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