FIGURE

Fig 5

ID

ZDB-FIG-200620-13

Publication

Ang et al., 2020 - Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish

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Fig 5

Absence of proliferation in <italic>mdka</italic><sup><italic>mi5001</italic></sup> following the death of inner retinal neurons.

(A, B) Immunocytochemistry for the cell marker, HuC/D, in wildtype (A) and mdka^mi5001 (B) at 72 hpi. (C) The number of HuC/D-positive cells following the injection of PBS (wildtype: 241.3 ± 28.2 cells, mdka^mi50011: 206.0 ± 12.4 cells) and ouabain (wildtype: 25.8 ± 10.5 cells, mdka^mi5001: 17.2 ± 7.2 cells, p = 0.137) retinas. (D, E) Immunocytochemistry for proliferative marker, PCNA in wildtype (D) and mdka^mi5001 (E) at 72 hpi. (F) The number of PCNA-positive cells per 500 μm in wildtype (54.4 ± 14.2 cells) and mdka^mi5001 (17.1 ± 6.4 cells. p = 0.00246) at 72 hpi. Student’s t-test, p*<0.05, n = 9 wildtype and 9 mutants. ONL: outer nuclear layer; INL: inner nuclear layer.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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