FIGURE

Fig. 4.

ID

ZDB-FIG-200608-18

Publication

Ates et al., 2020 - Deficiency in the endocytic adaptor proteins PHETA1/2 impair renal and craniofacial development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4.

Loss of pheta1/2 disrupts craniofacial development. (A,B) Alcian Blue and Alizarin Red staining in 6 dpf animals. Structures are as indicated in the leftmost images. (A) Ventral view of the lower jaw. Representative images from each genotype are shown. Images are quantified in panels C-H. Scale bars: 200 µm. (B) Flat-mount preparations of the lower jaw at 6 dpf. Arrowheads point to where osteogenesis occurs within the ceratohyal cartilage. The number of animals imaged with displayed phenotype is shown in the lower-left corner of each image. Scale bars: 100 µm. (C-H) Morphological measurements of 6 dpf larvae, with the measured distance/area highlighted in red in the above schematics. bsr, brachiostegal ray; ch, ceratohyal; en, entopterygoids; hs, hyosymplectic; m, Meckel's cartilage; op, opercle; pq, palatoquadrate. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pheta1^vt2/vt2 pheta2^vt3/vt3 pheta1^vt2/vt2; pheta2^vt3/vt3
Observed In:	ceratohyal bone ossification ceratohyal cartilage cranium Meckel's cartilage palatoquadrate arch ventral mandibular arch
Stage:	Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.