FIGURE

Fig. 7

ID

ZDB-FIG-200406-153

Publication

Zhao et al., 2020 - Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis

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Fig. 7

Retina development in atp7a^−/− mutant treated with copper. A TEM analysis of retinal cells in copper-stressed atp7a^−/− mutant embryos at 96 hpf. A1-A3, sagittal slides of retina, red color indicating mitochondria and green color indicating ER. B Quantitative PCR of ROS related genes (B1; cox4i2, hmox2, lox, and nrf2), UPR related genes (B2; ire1a, perk, and atf6), and retinal genes (B3; opn1wl1, opn1sw1, opn1sw2 and rhodopsin) in atp7a^−/− mutants. C WISH assays of ER stress marker bip and chop in atp7a^−/− mutants. D WISH assays of retinal marker (opn1wl1 and opn1sw1) in atp7a^−/− mutants. C1-C8, lateral view, anterior to the left, D1-D8, dorsal view, anterior to the up. Scale bar: A1-A3, 1 μm; C1-C8 and D1-D4, 100 μm; **, P < 0.01; *, P < 0.05

Expression Data

Genes:	atf6 cox4i2 ddit3 eif2ak3 ern1 hmox2a hspa5 loxa opn1lw1 opn1sw1 opn1sw2 rho znrf2a
Fish:	AB atp7a^hza4/hza4
Conditions:	chemical treatment: copper(2+) chemical treatment: copper atom
Anatomical Terms:	brain retina whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp7a^hza4/hza4
Conditions:	chemical treatment: copper(2+) chemical treatment: copper atom
Observed In:	brain retina retina mitochondrion whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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