FIGURE

Fig. 3

ID

ZDB-FIG-191230-668

Publication

Pérez-Rius et al., 2019 - Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit

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Fig. 3

Myelin vacuolization in Glialcam^−/−, Mlc1^−/− and Glialcam^−/−Mlc1^−/− mouse models. Haematoxylin-eosin staining of sagittal sections of the cerebellum of 19- and 61-week-old mice showed similar levels of myelin vacuolization in Glialcam^−/−, Mlc1^−/− and Glialcam^−/−Mlc1^−/− animals. As a control we show the same area of a wild-type mouse at 19 weeks. The inset shows the percentage of vacuolation in double KO animal versus the vacuolation observed in Glialcam KO animals (n = 3) and Mlc1 KO animals (n = 3) considering each age independently, without substracting the minor vacuolization observed in wild-type animals. Data were analyzed by GraphPad Prism software. In order to compare the different groups (dKO vs Glialcam^−/− and dKO vs Mlc1^−/−), one-way analysis of variance (ANOVA) followed by post-hoc Bonferroni’s multiple comparison test was used. ns: not significative. Scale bar, 400 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Orphanet J Rare Dis