FIGURE

Fig. 4.

ID

ZDB-FIG-191230-1892

Publication

Liu et al., 2019 - Combinatorial genetic replenishments in myocardial and outflow tract tissues restore heart function in tnnt2 mutant zebrafish

Other Figures

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Fig. 4.

Mechanical behaviours of OFT are deregulated in tnnt2a mutant zebrafish with myocardial tnnt2a supplementation. (A) Representative images of the OFT morphologies at systole and diastole stages of a cardiac cycle. V, ventricle; A, atrium; yellow dotted line, heart outline; white line, OFT diameter; purple dotted line, OFT outline. Scale bar: 100 µm. (B) Statistics of maximum diameter difference of OFT in tnnt2a^+/+, tnnt2a^−/− and Tg(myl7:tnnt2a); tnnt2a^−/−. ****P<0.0001; n=30 per group. Statistical differences were evaluated using Kruskal–Wallis test. (C) Images of the stacked blood cells in the heart chambers of tnnt2a^−/− and Tg(myl7:tnnt2a); tnnt2a^−/− zebrafish at 72 hpf. Arrows show the stacked red blood cells. Scale bars: 100 µm.

Expression Data

Genes:	myl7 tnnt2a
Fish:	WT
Anatomical Terms:	bulbus arteriosus smooth muscle cell heart myocardium
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tnnt2a^{fdu108/fdu108}; fdu106Tg
Condition:	chemical treatment by environment: doxycycline
Observed In:	bulbus arteriosus heart contraction
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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