(A and B) Sagittal sections of the adult brain of wild-type (A) and mfsd2aa mutants (B) reveals increased extravasation of the transgenic DBP-EGFP serum fusion protein (green) in the forebrain (FB), midbrain (MB) and hindbrain (HB) of mfsd2aa mutants compared to wild-type siblings. The scale bar represents 100 µm. (C) Quantification of normalized parenchymal DBP-EGFP tracer intensity in the forebrain, midbrain and hindbrain of wild-type (black) and mfsd2aa mutants (magenta) reveals that mfsd2aa mutants have significantly increased levels of DBP-EGFP permeability throughout the adult brain. Parenchymal tracer intensity outside of the vasculature was measured in 6 distinct areas, averaged and normalized to the blood vessel DBP-EGFP intensity for each region (FB, MB and HB) and displayed as a single point for each fish. The mean and the standard error are drawn as black lines. ****p<0.0001 by t test.
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