FIGURE

Figure 8

ID

ZDB-FIG-191230-1097

Publication

Chen et al., 2019 - Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency

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Figure 8

The locomotor activity of zPnpo morphants at 4 dpf. Zebrafish larvae with the indicated treatment were placed individually in each well on a 48-well plate and rested in the tested chamber for 5 min before recording. (A) The swimming track, representing larval cumulative location in 1 min, was recorded. (B–E) Larval swimming behavior was recorded for 30 min and analyzed for velocity (B), maximum acceleration (C), body activity (D), and absolute turning angle (E) with the built-in analytic software in DanioVision High-throughput tracking system. Reported are the averages of data from at least three independent repeats with n = 30∼164 embryos for each group and expressed as mean ± SEM. The statistical significance was calculated with one-way ANOVA (Kruskal–Wallis test) by comparing the experimental groups with wild type (*) or with zPnpo MO (#). ^#p < 0.05; ^##p < 0.01; ***/^###p < 0.001. MO, morpholino oligonucleotide; ANOVA, analysis of variance.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-pnpo
Conditions:	chemical treatment by environment: pyridoxal chemical treatment by environment: pyridoxal 5'-phosphate chemical treatment by environment: pyridoxamine chemical treatment by environment: pyridoxine
Knockdown Reagent:	MO1-pnpo
Observed In:	swimming behavior
Stage:	Day 4

Phenotype Detail

Acknowledgments

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