Fig. 8

Microphonic potentials of mir-183/96^lri69 and mir-183/96/182^lri78 fish are reduced. (a,b) Representative microphonic potentials obtained from lateral line neuromasts of mir-183/96^lri69 (a) and mir-183/96/182^lri78 (b) fish. The top trace in each panel shows pressure applied to a stimulating puff pipette. Traces of microphonic potential recordings from neuromasts are shown below. (c) Summary of microphonic potentials from mir-183/96^lri69 fish. Each point represents the average of maximal peak to peak amplitudes of responses produced from anterior and posterior deflections of the cupula. (d) Number of hair cells per neuromast in mir-183/96^lri69 fish that were observable with brightfield imaging during recording. (e) Microphonic potentials from mir-183/96^lri69 fish, normalized to the number of observable bundles in the neuromast. (f) Summary of microphonic potentials from mir-183/96/182^lri78 fish. (g) Number of hair cells per neuromast in mir-183/96/182^lri78 fish. (h) Microphonic potentials from mir-183/96/182^lri78 fish, normalized to the number of observable bundles in the neuromast. (I,j) Representative neuromasts of mir-183/96^lri69 (i) and mir-183/96/182^lri78 (j) fish, imaged during recording. Arrows indicate normal stereocilia bundles, arrowheads indicate small and disorganized bundles. c-e, Student’s t-test; f-h, ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.