FIGURE

Fig. 2.

ID

ZDB-FIG-190723-877

Publication

Gjini et al., 2019 - Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

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Fig. 2.

Asxl1 loss affects organ development. Histopathological analysis of the muscle, intestine and liver development with hematoxylin and eosin staining in 5 asxl1^+/+ and 5 asxl1^−/− mutants at 6 dpf and 14 dpf. Muscle (A,D) and intestine (B,E) development had no difference between asxl1^+/+ and asxl1^−/− embryos at 6 dpf. Liver parenchyma at 6 dpf appeared abnormal with vacuolated cells in asxl1^−/− embryos (F) compared with asxl1^+/+ embryos (C). At 14 dpf, muscular atrophy was shown in asxl1^−/− embryos (J) compared with normal striated muscle in asxl1^+/+ embryos (G). Intestine in asxl1^−/− embryos was abnormal with villus blunting (K) compared with normal nuclei and microvilli in the asxl1^+/+ embryos (H). The asxl1^−/− embryos exhibited progressive liver architectural distortion (L) compared to asxl1^+/+ embryos (I).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	asxl1^zdf34/zdf34
Observed In:	hepatocyte hepatocyte anatomical boundary intestinal villus intestine intestine nucleus liver muscle muscle nucleus muscle cell
Stage Range:	Day 6 to Days 14-20

Phenotype Detail

Acknowledgments

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