FIGURE

FIGURE 3

ID

ZDB-FIG-190723-802

Publication

Nelson et al., 2019 - Glucocorticoids Target Ependymal Glia and Inhibit Repair of the Injured Spinal Cord

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FIGURE 3

Glucocorticoids inhibit the formation of trans-lesion glial bridges. (A–F) Whole-mount preparations (lateral view) of Tg(gfap:EGFP) transgenic zebrafish show immunostaining for EGFP (green) and DAPI staining (blue) from 24 h post sham injury (A,B), 24 h post SCI with no treatment (C,D) and 24 h post SCI+Dex (E,F). EGFP-positive ependymal glia were observed spanning the lesion site at 24 h post SCI in controls (C,D), and were absent with Dex (E,F). Boxed regions (A,C,E) are magnified by 175% (B,D,F, respectively). Scale bars, 50 μm (A is the same as C,E; B is the same as D,F). Representative images from 10 preparations per condition. (G) Counts of glial bridges at 24 h post SCI in and 24 h post SCI+Dex.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol